For minor aches, acetaminophen (Tylenol) is generally better tolerated than ibuprofen (Advil) in terms of side effects. For joint pain, you should know that ibuprofen is FDA-approved to treat rheumatoid arthritis and osteoarthritis. Ibuprofen is usually more effective than acetaminophen in treating back pain and toothaches. Acetaminophen does not have blood-thinning effects. Most NSAIDs (nonsteroidal anti-inflammatory drugs), such as aspirin, will affect blood clotting (coagulation), an effect commonly called "thinning the blood," but acetaminophen does not cause this side effect. This means it may be the best option for pain relief or fever if you're already on There are three options: Tricyclic antidepressants, such as amitriptyline (Elavil), doxepin (Sinequan), and nortriptyline (Pamelor). These drugs are prescribed for pain at doses lower than are effective for depression. Serotonin–norepinephrine reuptake inhibitors (SNRIs), such as duloxetine (Cymbalta) and venlafaxine (Effexor). Analgesic and antipyretic action. Aspirin is a weaker analgesic than morphine-type drugs, that is Aspirin 600mgFquJI.